Keloid Treatment Options: Injections, Surgery, and Combination Therapy

You're standing in front of the mirror, and there it is—a raised, shiny scar that's grown far beyond the original wound. It's not painful, but it's noticeable, and you can't help wondering: Will this ever go away? If you're dealing with a keloid, you're not alone. These stubborn scars affect millions of people, and the good news is that effective treatment options exist. Whether you're considering steroid injections, surgical removal, or a combination approach, understanding your options is the first step toward feeling confident in your skin again.

Key Takeaways

  • Keloids are benign overgrowths of scar tissue that extend beyond the original wound and don't resolve on their own
  • Corticosteroid injections remain the first-line treatment for most keloids, with success rates of 50-100% when combined with other therapies
  • Surgical excision alone has high recurrence rates (45-100%), but combining surgery with radiation or steroid injections significantly improves outcomes
  • Combination therapy offers the best long-term results, often pairing surgery with post-operative radiation or intralesional injections
  • Early intervention is crucial—treating keloids when they're smaller and newer typically yields better results

Understanding Keloids: More Than Just a Scar

Before we dive into treatment options, let's talk about what keloids actually are. Unlike normal scars that fade over time, keloids are aggressive. They're raised, firm, and often shiny scars that grow beyond the boundaries of the original injury. They can develop from something as minor as a piercing, acne, or a small cut—and they don't discriminate, though they're more common in people with darker skin tones.

Here's what makes keloids different from regular scars:

  • They extend beyond the original wound boundary
  • They don't regress on their own over time
  • They can continue growing for months or even years
  • They may be itchy or tender, especially during growth phases
  • They have a genetic component—if your family members have keloids, you're more likely to develop them

The challenge with keloids isn't just cosmetic. They can cause discomfort, limit movement if they're over joints, and significantly impact your quality of life. That's why finding the right treatment approach matters.

The First Line of Defense: Corticosteroid Injections

When it comes to keloid treatment, corticosteroid injections are often where we start—and for good reason. They're minimally invasive, relatively affordable, and can be remarkably effective for the right candidates.

How Steroid Injections Work

Corticosteroid injections, typically using triamcinolone acetonide, work by:

  • Reducing inflammation within the keloid tissue
  • Decreasing collagen production that causes the scar to grow
  • Softening and flattening the raised tissue
  • Reducing redness and itchiness

The procedure itself is straightforward. We inject the medication directly into the keloid tissue using a fine needle. Yes, it can be uncomfortable—keloids are dense tissue—but most patients tolerate it well. You'll typically need multiple sessions, usually every 4-6 weeks, to see optimal results.

Success Rates and What to Expect

Response rates vary, but here's what the research tells us:

Treatment ApproachSuccess RateTypical TimelineSteroid injections alone50-80% improvement3-6 months (multiple sessions)Steroids + 5-FU75-90% improvement2-4 monthsSteroids + cryotherapy60-85% improvement3-5 months

Who's a Good Candidate?

Steroid injections work best for:

  • Small to medium-sized keloids (under 2cm)
  • Newer keloids (less than 2 years old)
  • Patients who want to avoid surgery
  • Keloids in cosmetically sensitive areas where surgery might create more scarring

Potential Side Effects

Like any treatment, steroid injections come with possible side effects:

  • Temporary pain or discomfort during injection
  • Skin discoloration (hypopigmentation) at the injection site
  • Skin thinning (atrophy) with repeated injections
  • Telangiectasia (small visible blood vessels)

The good news? These side effects are usually temporary and manageable. At The Minor Surgery Center, we carefully adjust dosing and technique to minimize these risks while maximizing results.

When Surgery Makes Sense: Surgical Excision for Keloids

Sometimes, injections alone aren't enough—especially for larger, older, or more resistant keloids. That's when surgical excision becomes part of the conversation.

The Surgical Approach

Surgical removal of a keloid involves completely excising the scar tissue under local anesthesia. It sounds straightforward, but here's the catch: keloids are notoriously prone to recurrence after surgery. In fact, if you remove a keloid surgically without any additional treatment, the recurrence rate can be as high as 45-100%.

That's why we rarely perform keloid surgery as a standalone treatment. Instead, we combine it with other therapies to prevent that aggressive scar tissue from coming back.

Types of Surgical Techniques

Different surgical approaches may be used depending on the keloid's size and location:

Complete excision: Removing the entire keloid down to normal skin level

Core excision: Removing the bulk of the keloid while leaving a thin rim of tissue to reduce tension on the wound

Intralesional excision: Removing the keloid from within, preserving the outer layer

Each technique has its place, and the choice depends on factors like keloid size, location, and your individual healing characteristics.

Who Should Consider Surgery?

Surgery might be the right choice if you have:

  • 🔹 Large keloids that haven't responded to injections
  • 🔹 Keloids that interfere with function (like those over joints)
  • 🔹 Pedunculated keloids (those with a stalk-like base)
  • 🔹 Keloids in less visible areas where a new surgical scar is acceptable

The Reality About Surgical Risks

Let's be honest: keloid surgery comes with real risks. Beyond the standard surgical risks like infection or bleeding, the biggest concern is recurrence—and the new keloid can be even larger than the original.

That's why patient selection is crucial. We need to carefully weigh whether the benefits outweigh the risks for your specific situation. During your consultation at our clinic, we'll have an open conversation about your expectations and the realistic outcomes.

The Game-Changer: Combination Therapy

Illustration for: Keloid Treatment Options: Injections, Surgery, and Combination Therapy

Here's where keloid treatment gets really interesting. While individual treatments have their place, combination therapy is where we see the most impressive and lasting results.

Why Combination Approaches Work Better

Think of keloids as a stubborn opponent. If you only attack from one angle, they find a way to come back. But when you use multiple strategies simultaneously or sequentially, you're much more likely to win the battle.

Combination therapy works because:

  • Different treatments target different mechanisms of keloid formation
  • Synergistic effects mean the combined impact is greater than individual treatments alone
  • Lower recurrence rates compared to any single treatment modality
  • Better cosmetic outcomes with less residual scarring

Proven Combination Strategies

Let's explore the most effective combination approaches:

1. Surgery + Post-Operative Radiation

This is one of the most successful combinations, particularly for large or resistant keloids.

How it works: Within 24-48 hours after surgical removal, we deliver targeted radiation to the surgical site. This prevents the aggressive scar tissue from reforming.

Success rate: 70-90% prevention of recurrence

Best for: Large keloids, keloids that have recurred after previous treatments

Considerations: Radiation therapy requires specialized equipment and carries its own risks, so it's typically reserved for challenging cases.

2. Surgery + Intralesional Steroid Injections

This is perhaps the most commonly used combination approach.

Protocol: After surgical removal, we begin steroid injections at the surgical site, usually starting 2-4 weeks post-operatively and continuing monthly for several months.

Success rate: 60-85% prevention of recurrence

Best for: Medium to large keloids in patients who want to avoid radiation

Advantage: Lower risk profile than radiation therapy

3. Steroid Injections + 5-Fluorouracil (5-FU)

This combination has gained popularity for non-surgical keloid management.

How it works: 5-FU is a chemotherapy agent that inhibits fibroblast proliferation (the cells that create excessive scar tissue). When combined with steroids, it's more effective than either treatment alone.

Success rate: 75-95% improvement in keloid size and symptoms

Best for: Patients who want to avoid surgery, or as a post-surgical adjunct

Treatment schedule: Usually administered every 1-2 weeks for several months

4. Cryotherapy + Intralesional Injections

The approach: Freezing the keloid tissue with liquid nitrogen before or after steroid injections can enhance the treatment's effectiveness.

Success rate: 60-85% improvement

Best for: Smaller keloids, keloids on the earlobes

Benefit: Can reduce the number of injection sessions needed

Creating Your Personalized Treatment Plan

At The Minor Surgery Center, we don't believe in one-size-fits-all treatment. Your keloid treatment plan should consider:

  • Keloid characteristics: Size, location, age, symptoms
  • Your medical history: Previous treatments, skin type, healing tendencies
  • Your goals and preferences: Tolerance for risk, downtime, cost considerations
  • Evidence-based outcomes: What the research shows works best for keloids like yours

Emerging and Alternative Treatments Worth Knowing About

The field of keloid treatment continues to evolve. While the approaches we've discussed remain the gold standard, several emerging treatments show promise:

Laser Therapy

Pulsed dye lasers (PDL) and fractional CO2 lasers can reduce keloid redness, flatten the scar, and improve texture. They work best when combined with other treatments rather than used alone.

Silicone Gel Sheets and Pressure Therapy

These non-invasive approaches can help prevent keloid formation after injury or surgery, and may modestly improve existing keloids. They're low-risk options worth trying, especially for prevention.

Cryotherapy (Standalone)

Freezing keloid tissue can be effective for smaller keloids, particularly on the earlobes. Success rates vary from 50-75%, and multiple sessions are typically needed.

Interferon Injections

Interferon can inhibit fibroblast proliferation and collagen synthesis. While promising, it's more expensive than steroids and not yet widely available.

Bleomycin Injections

This chemotherapy agent shows promise for keloid treatment, with success rates comparable to steroid injections but potentially fewer side effects.

What About Prevention? Can You Stop Keloids Before They Start?

If you're prone to keloids, prevention is your best strategy. Here's what actually works:

After any injury or procedure:

  • Apply silicone gel sheets or ointment for at least 12 weeks
  • Use pressure therapy if appropriate (like pressure earrings after ear piercing)
  • Avoid unnecessary trauma to the skin
  • Consider prophylactic steroid injections after surgical procedures

Lifestyle considerations:

  • Avoid elective procedures in high-risk areas (like cosmetic piercings)
  • If you must have surgery, discuss keloid prevention strategies with your surgeon
  • Treat any skin injuries or infections promptly to minimize scarring

Making the Decision: Which Treatment Is Right for You?

Choosing the right keloid treatment can feel overwhelming. Here's a framework to help you think through your options:

Start with These Questions:

How big is your keloid?

  • Small (under 1cm): Steroid injections, silicone therapy
  • Medium (1-3cm): Combination steroid therapy, consider surgery + adjunct treatment
  • Large (over 3cm): Surgery + radiation or intensive combination therapy

How long have you had it?

  • Recent (under 1 year): Excellent response to conservative treatments
  • Established (1-5 years): May need more aggressive combination approach
  • Long-standing (over 5 years): Often requires surgery plus adjunct therapy

Has it been treated before?

  • First treatment: Start with less invasive options
  • Previous treatment failure: Consider more aggressive combination therapy
  • Multiple recurrences: Surgery + radiation may be necessary

Where is it located?

  • Cosmetically sensitive areas: Start conservative, minimize surgical risk
  • Over joints: May need surgery if limiting function
  • Earlobes: Excellent response to cryotherapy or surgery

The Consultation Process

When you visit us to discuss keloid treatment options, here's what to expect:

  1. Comprehensive evaluation of your keloid's characteristics
  2. Review of your medical history and previous treatments
  3. Discussion of realistic outcomes for each treatment option
  4. Personalized treatment plan tailored to your specific situation
  5. Clear explanation of costs, timeline, and what to expect

We believe in transparent communication. You deserve to understand not just what we recommend, but why we recommend it.

The Treatment Journey: What to Expect

Illustration for: Keloid Treatment Options: Injections, Surgery, and Combination Therapy

Let's walk through what the treatment process actually looks like, depending on which approach you choose.

If You Choose Injection Therapy

Initial visit: Evaluation and first injection session (15-20 minutes)

Follow-up sessions: Every 4-6 weeks until optimal improvement

Timeline: Most patients see noticeable improvement within 2-3 months

Aftercare: Minimal—you can return to normal activities immediately

Monitoring: We'll track progress with photos and measurements

If You Choose Surgical Excision with Combination Therapy

Pre-operative consultation: Detailed planning and consent

Surgery day: Outpatient procedure under local anesthesia (30-60 minutes)

Immediate post-op: Pressure dressing applied, detailed care instructions

First week: Wound care, activity restrictions, pain management

Follow-up schedule:

  • Week 1: Wound check
  • Weeks 2-4: Suture removal, begin adjunct therapy
  • Months 2-6: Regular monitoring and continued adjunct treatments

Long-term: Ongoing surveillance for early detection of any recurrence

Managing Expectations

Here's what I want you to know: keloid treatment requires patience. Unlike removing a simple mole or cyst, keloids don't disappear overnight. Successful treatment is a process, not an event.

Most patients see:

  • Initial improvement within 4-8 weeks
  • Significant improvement by 3-6 months
  • Optimal results at 6-12 months
  • Continued subtle improvement up to 18 months

Cost Considerations and Insurance Coverage

Let's talk about the financial side—because I know it matters.

Typical costs (these vary by location and provider):

  • Steroid injection session: $100-$300 per session
  • Surgical excision: $500-$2,500 depending on size and complexity
  • Radiation therapy: $1,000-$5,000 for full course
  • Combination therapy: Variable, depending on components

Insurance coverage: Many insurance plans cover keloid treatment, especially when the keloid causes symptoms (pain, itching, functional limitation) or results from a medical procedure. Purely cosmetic removal may not be covered.

At The Minor Surgery Center, we're committed to transparency about costs. We'll provide clear pricing upfront and help you understand your insurance benefits.

Real Patient Outcomes: What Success Looks Like

Success with keloid treatment isn't always about complete elimination—though that's certainly possible. For many patients, success means:

  • Significant flattening of the raised scar
  • Reduction in size by 50% or more
  • Improved color and texture matching surrounding skin better
  • Relief from symptoms like itching or tenderness
  • Restored confidence and reduced self-consciousness

The most successful outcomes happen when patients:

  • Start treatment early (newer keloids respond better)
  • Commit to the full treatment course (not stopping after one or two sessions)
  • Follow aftercare instructions carefully
  • Maintain realistic expectations
  • Work with experienced providers who specialize in keloid treatment

When to Seek Professional Help

You should consult a specialist about keloid treatment if:

  • 🔴 Your keloid is growing or changing
  • 🔴 It's causing pain, itching, or other symptoms
  • 🔴 It's affecting your quality of life or self-confidence
  • 🔴 You've tried over-the-counter treatments without success
  • 🔴 You're planning surgery or a procedure and want to prevent keloid formation
  • 🔴 A previous keloid treatment didn't work or the keloid recurred

Don't wait until a keloid becomes massive. Early intervention typically yields better results with less aggressive treatment.

Your Next Steps: Taking Action

If you're ready to address your keloid, here's what I recommend:

Step 1: Schedule a consultation with a specialist experienced in keloid treatment. At The Minor Surgery Center, our team has extensive experience with all keloid treatment modalities.

Step 2: Come prepared with questions. Write down what matters most to you—whether that's treatment timeline, cost, or specific outcome goals.

Step 3: Be honest about your medical history, including any previous keloid treatments and how you typically heal from injuries.

Step 4: Commit to the recommended treatment plan. Consistency is key with keloid therapy.

Step 5: Stay patient and trust the process. Remember, keloid improvement is gradual.

Frequently Asked Questions About Keloid Treatment

Can keloids be permanently removed?

While keloids can be successfully treated and significantly improved, there's always some risk of recurrence. Combination therapies offer the best chance of long-term success, with recurrence rates as low as 10-30% when properly managed.

Does keloid removal hurt?

Most keloid treatments involve some discomfort, but it's manageable. Injections can be uncomfortable during administration but don't cause lasting pain. Surgical removal is performed under local anesthesia, so you won't feel pain during the procedure, though there's typical post-surgical discomfort.

How long does keloid treatment take?

It depends on the approach. Injection therapy typically requires 3-6 sessions over several months. Surgical treatment is a one-time procedure, but post-operative adjunct therapy may continue for 6-12 months.

Will insurance cover my keloid treatment?

Many insurance plans cover keloid treatment when it's medically necessary (causing symptoms or functional problems). Coverage for purely cosmetic removal varies. We can help you navigate insurance questions—just contact us to discuss your specific situation.

Can keloids come back after treatment?

Yes, recurrence is possible with any treatment. That's why combination therapy is so important—it significantly reduces recurrence risk. Following all aftercare instructions and attending follow-up appointments also helps prevent recurrence.

For more answers to common questions, visit our FAQs page.

Conclusion: You Have Options, and You Deserve Expert Care

Living with a keloid doesn't have to be permanent. Whether you're dealing with a small keloid that's just starting to develop or a large, established scar that's been bothering you for years, effective treatment options exist.

The key is finding the right approach for your specific situation. Steroid injections offer a minimally invasive starting point for many patients. Surgical excision, when combined with appropriate adjunct therapies, can address larger or more resistant keloids. And combination therapy—whether that's surgery plus radiation, injections plus 5-FU, or other strategic combinations—offers the best chance of long-term success.

At The Minor Surgery Center, we're committed to helping you feel confident in your skin again. We combine medical expertise with compassionate care, creating personalized treatment plans that respect your goals, concerns, and individual healing characteristics.

You don't have to navigate this alone. Our experienced team is here to guide you through every step—from initial consultation through treatment and long-term follow-up. We'll take the time to explain your options, answer your questions, and develop a treatment strategy that makes sense for you.

Ready to take the next step? Contact us today to schedule your keloid consultation. Let's work together to find the treatment approach that's right for you.

Because you deserve expert care, delivered with compassion—and results that help you feel like yourself again.

October 6, 2025